Journal of Endocrinology and Reproduction

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Streptozotocin-Diabetes Impairs the Differentiation of Epididymis during Sexual Maturation


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1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
     

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Male reproductive dysfunction is a common feature in diabetic boys and men. Defective spermatogenesis, sperm count, sperm motility, seminal fluid volume and serum testosterone, supports endocrine basis for impotence and fertility disorders. The present investigation was carried out to understand the impact of diabetes on the structure and development of epididymis during the critical period of sexual maturation in rats. Prepubertal (40 days old) and adult (120 days old) male Wistar rats were made diabetic by single injection of streptozotocin (120 mg/kg body weight for prepubertal and 65 mg/kg body weight for adult) intraperitoneally.
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  • Streptozotocin-Diabetes Impairs the Differentiation of Epididymis during Sexual Maturation

Abstract Views: 252  |  PDF Views: 0

Authors

S. Singh
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
S. Yuvaraj
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
R. Sivakumar
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
C. Parthasarathy
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
T. Malini
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
K. Balasubramanian
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India

Abstract


Male reproductive dysfunction is a common feature in diabetic boys and men. Defective spermatogenesis, sperm count, sperm motility, seminal fluid volume and serum testosterone, supports endocrine basis for impotence and fertility disorders. The present investigation was carried out to understand the impact of diabetes on the structure and development of epididymis during the critical period of sexual maturation in rats. Prepubertal (40 days old) and adult (120 days old) male Wistar rats were made diabetic by single injection of streptozotocin (120 mg/kg body weight for prepubertal and 65 mg/kg body weight for adult) intraperitoneally.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F99259