Journal of Endocrinology and Reproduction

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Effect of Polychlorinated Biphenyl (Aroclor 1254) on Rat Leydig Cellular Antioxidant System


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1 Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, India
     

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To find out the effect of polychlorinated biphenyl compound Aroclor 1254 on rat Leydig cellular antioxiSant system, adult male rats were exposed to Aroclor 1254 (2 mg/kg b.wt.) mixed with com oil through intraperitoneal (ip) injection daily for 30 days. The control rats were administered com oil as vehicle. Testes were removed on the both groups and Leydig cells were isolated by enzymatic digestion and purified on discontinous percoll gradient.
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  • Effect of Polychlorinated Biphenyl (Aroclor 1254) on Rat Leydig Cellular Antioxidant System

Abstract Views: 294  |  PDF Views: 0

Authors

P. Murugesan
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, India
J. Senthilkumar
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, India
K. Balasubramanian
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, India
M. M. Aruldhas
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, India
P. Govindarajulu
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, India
J. Arunakaran
Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600 113, India

Abstract


To find out the effect of polychlorinated biphenyl compound Aroclor 1254 on rat Leydig cellular antioxiSant system, adult male rats were exposed to Aroclor 1254 (2 mg/kg b.wt.) mixed with com oil through intraperitoneal (ip) injection daily for 30 days. The control rats were administered com oil as vehicle. Testes were removed on the both groups and Leydig cells were isolated by enzymatic digestion and purified on discontinous percoll gradient.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F99272