Journal of Endocrinology and Reproduction

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Role of RhIGF-I on Differentiation and Mineralization of Rat Bone Marrow Stem Cells


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1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
     

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Bone marrow stem cells (BMSC) develop into pre-osteoblast, mature into osteoblast and attain sensitivity as osteocytes. Among the potential regulators of bone formation, insulin like growth factor-I (IGF-I) occupies an important position because of its ability to stimulate osteoblast proliferation and differentiation. Although, it is well known that osteoblasts are important target cell types, little is known about the effect of rhIGF-I on osteoprogenitors.
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  • Role of RhIGF-I on Differentiation and Mineralization of Rat Bone Marrow Stem Cells

Abstract Views: 249  |  PDF Views: 0

Authors

S. Veni
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
E. Thirupavai
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
S. Sitta Djody
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
R. Ilangovan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India
N. Srinivasan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, India

Abstract


Bone marrow stem cells (BMSC) develop into pre-osteoblast, mature into osteoblast and attain sensitivity as osteocytes. Among the potential regulators of bone formation, insulin like growth factor-I (IGF-I) occupies an important position because of its ability to stimulate osteoblast proliferation and differentiation. Although, it is well known that osteoblasts are important target cell types, little is known about the effect of rhIGF-I on osteoprogenitors.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F99281