Journal of Environment and Sociobiology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

An Appraisal Of Scope And Prospect Of Plant Metabolites Against Covid-19 Pandemic


Affiliations
1 Department of Biotechnology, Brainware University, 398, Ramkrishnapur Road, Kolkata-700125, India
     

   Subscribe/Renew Journal


Covid (Corona-virus disease) caused by SARS COV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) triggered in recent past a worldwide fatal which posed challenges before global healthcare system. Apart from extensive researches for development of effective therapeutics against this viral disease several plant metabolites have been taken into account for treatment of Covid symptoms like weakness, cough and cold. Several biologically active components viz., “Allicin”, “Diallyltrisulfide”, “Saponin”, “Menthol”, “Carvacrol” extracted from plants took more attention to cure severe fatal pandemics. A lot of research works has been done in recent times on the production of effective therapeutics against this global pandemic, but still there is no approved therapy against the Covid-19 pandemic. We have herein reviewed some biologically active plant-synthesized secondary metabolites, which have prospect against SARS COV-2 as therapeutic agents.

Keywords

Covid-19, Pandemic, Secondary metabolites, Symptoms, Therapeutics.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Bagde, H. and Dhopte, A. 2022. Effect of plant metabolites on the growth of COVID-19 (Corona Virus Disease-19) including Omicron strain. Cureus, 14(7): DOI: 10.7759 cureus.26549.

  • Bhuiyan, F. R., Howlader, S., Raihan, T. and Hasan, M. 2020. Plants metabolites: possibility of natural therapeutics against the COVID-19 Pandemic. Front. Med. (Lausanne), 7: 444. https:///doi.org/: 10.3389/f med.2020.00444

  • Ehrhardt, C. and Ludwig, S. 2009. A new player in a deadly game: influenza viruses and P13K/Akt signaling pathway. Cell. Microbiol., 11(6): 863-871.

  • Gruhlke, M. C. H., Antelmann, H., Bernhardt, J., Kloubert, V., Rink, L. and Slusarenko, A. J. 2019. The human allicin-proteome: S-thioallylation of proteins by the garlic defense substance allicin and its biological effects. Free Radic. Bio. Med., 131: 144-153.

  • Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, I., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., Gao, H., Guo, L., Xie, J., Wang, G., Jiang, R., Gao, Z., Jin, Q., Wang, J. and Cao, B. 2020. Clinical features of patients with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223): 497-506.

  • Kensil, C. R. 1996. Saponins as vaccine adjuvants. Crit. Rev. Ther. Drug Carrier Syst., 13(1-2): 1-55.

  • Rajput, Z. I., Hu, S-H., Xiao, C-W. and Arijo, A. G. 2007. Adjuvant effects of saponins on animal immune responses. J. Zhejiang Univ. Sci. B., 8(3): 153-161.

  • Rath, B., Hochmair, M., Plangger, A. and Hamilton, G. 2018. Anticancer activity of Fascaplysin against lung cancer cell and small cell lung cancer circulating tumor cell lines. Mar. Drugs, 16(10): 383. DOI: 10.3390/md.16100383.

  • Riou, M., Marcot, C., Canuet, M., Renaud-Picard, B., Chatron, E., Porzio, M., Dégot, T., Hirschi, S., Metz-Favre, C., Kassegne, L., Ederle, C., Khayath, N., Labani, A., De Blay, F. L., Kessler, R. and COVID-19 pneumonia group. 2021. Clinical characteristics of and outcomes for patients with COVID-19 and comorbid lung diseases primarily hospitalized in a conventional pulmonology unit: a retrospective study. Respir. Med. Res., 79: 100801. DOI: 10.1016/j. resmer.2020.100801

  • Rouf, R., Jamal Uddin, S., Sarker, D. K., Islam, M. T., Ali, E. S., Shilpi, J. A., Nahar, L., Tiralongo, E. and Sarker, S. D. 2020. Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: a systematic update of pre-clinical and clinical data. Trends. Food Sci. Technol., 104: 219-234.

  • An appraisal of scope and prospect of plant metabolites against covid-19 pandemic

  • Takashi, H., Sato, A., Nakaguchi, N., Ozaki-Masuzawa, Y. and Seki, T. 2020. Diallyl trisulfide inhibits platelet aggregation through the modification of sulfhydryl groups. J. Agric. Food Chem., 68(6): 1571-1578.

  • Taylor, D. J. R, Hamid, S. M., Andres, A. M,, Saadaeijahromi, H. P., Piplani, H., Germano, J. F, Song, Y., Sawaged, S., Feuer, R., Pandol, S. J. and Sin, J. 2000. Antiviral effects of menthol on coxsackievirus B. Viruses, 12(4): 373. DOI: 10.3390/v12040373.

  • Verma, S., Abbas, M., Verma, S., Khan, F. H., Raza, S. T., Siddiqui, Z., Ahmad, I. and Mahdi, F. 2021. Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE 1) gene on the severity of COVID-19 patients. Infect. Genet. Evol., 91: 104801. DOI: 10.1016/meegid.2021.104801


Abstract Views: 241

PDF Views: 0




  • An Appraisal Of Scope And Prospect Of Plant Metabolites Against Covid-19 Pandemic

Abstract Views: 241  |  PDF Views: 0

Authors

Priyana SenGuha
Department of Biotechnology, Brainware University, 398, Ramkrishnapur Road, Kolkata-700125, India

Abstract


Covid (Corona-virus disease) caused by SARS COV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) triggered in recent past a worldwide fatal which posed challenges before global healthcare system. Apart from extensive researches for development of effective therapeutics against this viral disease several plant metabolites have been taken into account for treatment of Covid symptoms like weakness, cough and cold. Several biologically active components viz., “Allicin”, “Diallyltrisulfide”, “Saponin”, “Menthol”, “Carvacrol” extracted from plants took more attention to cure severe fatal pandemics. A lot of research works has been done in recent times on the production of effective therapeutics against this global pandemic, but still there is no approved therapy against the Covid-19 pandemic. We have herein reviewed some biologically active plant-synthesized secondary metabolites, which have prospect against SARS COV-2 as therapeutic agents.

Keywords


Covid-19, Pandemic, Secondary metabolites, Symptoms, Therapeutics.

References