The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

Fullscreen Fullscreen Off

The present study is designed to delineate the receptor mediated effect of melatonin in pituitary gland regulated thyroid secretions of hyperthyroid mice. Immuno histochemical study has been done to observe the melatonin receptors localization in pituitary gland. Western blot analysis was carried out to assess the expression patterns of melatonin receptors in pituitary gland and TSH receptors in thyroid gland. Hormonal analysis was done by ELISA kits. It was observed that introduction of melatonin reduced serum T3, T4, TSH hormones levels including thyroid TSH receptors those were fluctuated due to experimentally induced hyperthyroidism. The result has also shown the depletion of MT1 and MT2 receptors of pituitary gland due to melatonin treatment in hyperthyroidism. It may conclude that melatonin effects in pituitary regulated thyroid secretions by down regulation of pituitary MT1 and MT2 receptors in hyperthyroid condition.


Melatonin, Melatonin Receptors, Pituitary, Thyroid Hormones, TSH Hormone, TSH Receptor.
Font Size