Journal of Ecophysiology and Occupational Health

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Role of Interleukin-I Super Family in Progression of Osteoarthritis


Affiliations
1 Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007, India
2 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007, India
3 Department of Orthopaedics, King George Medical University, Lucknow – 226003, India
4 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, India
5 Department of Orthopedics, King George Medical University, Lucknow – 226003, India
 

Osteoarthritis (OA) is considered as multifactorial disorder characterized by erosion of articular cartilage, tightening of joint space, subchondral bone remodelling and internal synovial inflammation. OA reduces joint function progressively as a person gets older. The most important group of the cytokines or chemokines are pre-dominantly involving in the early progression of the disease includes IL-1, IL-6, IL-18 and TNF-a, etc. IL-1 family of cytokines are known to be strongest stimulus for progressive synthesis of Matrix Metallo Proteinases (MMPs). Large number of immune cells, chondrocytes and endothelial cells potentially secrete IL-1 with diverse effect on number of diseases. This review highlights the association of IL-1 family cytokine in OA.

Keywords

Cytokine, IL-1 Family, Mode of Action, Osteoarthritis.
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  • Role of Interleukin-I Super Family in Progression of Osteoarthritis

Abstract Views: 237  |  PDF Views: 135

Authors

Amit Kumar
Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007, India
Md Arshad
Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007, India
Ajai Singh
Department of Orthopaedics, King George Medical University, Lucknow – 226003, India
Asif Jafri
Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, India
Sabir Ali
Department of Orthopedics, King George Medical University, Lucknow – 226003, India
Manish Yadav
Department of Orthopedics, King George Medical University, Lucknow – 226003, India
Suchit Swaroop
Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007, India

Abstract


Osteoarthritis (OA) is considered as multifactorial disorder characterized by erosion of articular cartilage, tightening of joint space, subchondral bone remodelling and internal synovial inflammation. OA reduces joint function progressively as a person gets older. The most important group of the cytokines or chemokines are pre-dominantly involving in the early progression of the disease includes IL-1, IL-6, IL-18 and TNF-a, etc. IL-1 family of cytokines are known to be strongest stimulus for progressive synthesis of Matrix Metallo Proteinases (MMPs). Large number of immune cells, chondrocytes and endothelial cells potentially secrete IL-1 with diverse effect on number of diseases. This review highlights the association of IL-1 family cytokine in OA.

Keywords


Cytokine, IL-1 Family, Mode of Action, Osteoarthritis.



DOI: https://doi.org/10.18311/jeoh%2F2017%2F15979