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An Experimental Study of Ethanolic Seed Extract of Vigna mungo Linn. for Nootropic Activity on Albino Rats


Affiliations
1 Farooqia College of Pharmacy, Tilaknagar, Eidgahmaidan, Mysore - 570021, India
2 East West College of Pharmacy, Bangalore - 560091, India
 

Purpose: The present study was designed to evaluate the Nootropic potential of Ethanolic seed extracts of Vigna mungo.Linn.(ESVM).

Design/methodology/approach: The objective of the present study was achieved using following methods such as Clonidine induced hypothermia and Haloperidol induced catalepsy. This study was carried out to evaluate the effectiveness of the ethanolic seed extracts of Vigna mungo.Linn.(ESVM) as Nootropic drug.

Findings: In Clonidine induced hypothermia model, ESVM show significantly increased rectal temperature in animals, showing antagonistic effect of extract. The extract also shows significantly decreased Lithium induced head twitching indicating anti seritonergic properties.

Conclusion: The results concluded that Vigna mungo Linn plant has nootropic activity which is most useful for patients suffering from dementia.


Keywords

Ethanolic Seed Extracts of Vigna Mungo Linn. (ESVM), Nootropic Activity, Amnesia, Transfer Latency, Haloperidol, Clonidine, Hypothermia, Catalepsy.
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  • Malaz B, Britt P, Laura H, Russell H, Kathleen LN. Screening for Dementia in PrimaryCare: A Summary of the Evidence for the US Preventive Services Task Force.Ann Intern Med.2003;138:927-937.
  • Lee AY. Vascular dementia. Chonnam Med J. 2011;47 (2):66–71.
  • Dhumal JS, Yele SU ,Ghodekar SN. Evaluation of immunomodulatory activity of Vignamungo(L) heppe. J Pharma Phytother 2013;1(2):9–14.
  • Kiritikar KR , Basu BD. Indian Medicinal Plants, Second edition,International Book Distributers Dehradun, India. 2005;3(2) :795-798.
  • Khandelwal KR, Practical Pharmacognosy-Techniques and Experiments.Pune;Nirali Prakashan;2000.
  • OECD 2000. Acute Oral Toxicity-Acute Oral Toxic Class Method. Eleventh Addendum to the OECD Guidelines for the Testing of Chemicals. Organisation for Economic Co-operation and Development, Paris. Guideline 423, adopted 23.03.1996.
  • Farooq S M, Alla TR, VenkatRao N, Prasad K, Shalam, Nandakumar K, et al. A study on CNS effects of Milk extract of nuts of Semi-carpusana cardium (Anacardaceae).Pharma-cologyonline.2007;1:49-63.
  • Wielosz M , Kleinrok Z. Lithium induced head twitches in rats.J Pharmacy and Pharmacol 1979;31:410-414.
  • Ogren, S.O. Central serotonin neurons and learning in rats.,Biology of Serotonergic Transmission. John Wiley and Sons, Chichester, 1982:317
  • Bush ES, Mayer SE. 5-Hydroxytryptamine (serotonin) receptor agonist and antagonists, Goodman and Gillman's the Pharmacological Basis of Therapeutics, McGraw-Hill, New York, 9th edition.1996.249-263.

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  • An Experimental Study of Ethanolic Seed Extract of Vigna mungo Linn. for Nootropic Activity on Albino Rats

Abstract Views: 232  |  PDF Views: 113

Authors

Saleem Ahmed
Farooqia College of Pharmacy, Tilaknagar, Eidgahmaidan, Mysore - 570021, India
K. A. Sridhar
East West College of Pharmacy, Bangalore - 560091, India
Syed Aamir
Farooqia College of Pharmacy, Tilaknagar, Eidgahmaidan, Mysore - 570021, India
M. D. Salahuddin
Farooqia College of Pharmacy, Tilaknagar, Eidgahmaidan, Mysore - 570021, India
Monowar Hussain
Farooqia College of Pharmacy, Tilaknagar, Eidgahmaidan, Mysore - 570021, India
Sajjadpasha
Farooqia College of Pharmacy, Tilaknagar, Eidgahmaidan, Mysore - 570021, India

Abstract


Purpose: The present study was designed to evaluate the Nootropic potential of Ethanolic seed extracts of Vigna mungo.Linn.(ESVM).

Design/methodology/approach: The objective of the present study was achieved using following methods such as Clonidine induced hypothermia and Haloperidol induced catalepsy. This study was carried out to evaluate the effectiveness of the ethanolic seed extracts of Vigna mungo.Linn.(ESVM) as Nootropic drug.

Findings: In Clonidine induced hypothermia model, ESVM show significantly increased rectal temperature in animals, showing antagonistic effect of extract. The extract also shows significantly decreased Lithium induced head twitching indicating anti seritonergic properties.

Conclusion: The results concluded that Vigna mungo Linn plant has nootropic activity which is most useful for patients suffering from dementia.


Keywords


Ethanolic Seed Extracts of Vigna Mungo Linn. (ESVM), Nootropic Activity, Amnesia, Transfer Latency, Haloperidol, Clonidine, Hypothermia, Catalepsy.

References