Purpose: The formulation and evaluation of hydrodynamically balanced tablets of ranitidine hydrochloride for gastric drug delivery was the specific aim of this research. Method: The hydrodynamically balanced tablets were prepared by direct compression technique with different ratios of polymers like hydroxyproylmethyl cellulose (HPMC K 4M), Ethyl cellulose, Xanthan gum and Guar gum. The prepared tablets were evaluated for their weight variation, hardness, drug content, friability, floating lag time, floating duration, in vitro dissolution and accelerated stability studies at 40°C ± 2°C/75% RH ± 5% for eight weeks. Conclusion: The floating tablets of ranitidine hydrochloride (HCl) were evaluated for physicochemical characteristics like hardness, weight variation, friability, floating lag time and stability studies. The in vitro buoyancy studies, in vitro drug release studies and the results showed that the best formulation. F2 had sustained release up to 98% of ranitidine hydrochloride over a period of 24 h.
Keywords
Ranitidine Hydrochloride, Gastric Drug Delivery, Polymer, Hydrodynamically Balanced.
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