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The Effect of Enicostemma littorale Blume on Adrenaline-Induced Hypertensive Rats
Aim: The primary objective of the study was to investigate the possible effects of 70% Ethanolic extract of Enicostemma littorale Blume on adrenaline induced hypertensive rats. The hypertension was induced by Adrenaline at dose of 0.5 mg/kg i.p for 5 consecutive days.
Materials and Methods: The test doses of 250, 333.33 and 500mg of 70% Ethanolic extract of Enicostemma littorale (EEEL) and 10mg Propanolol were given orally and Intraperitonially respectively for 7 days. The various biochemical parameters like blood glucose, serum triglyceride, cholesterol, serum creatine phosphokinase, lactate dehydrogenase were measured.
Results: The extract administered groups had shown significantly lowered in LDH, CPK and pulse rate comparing to the normal groups. The biochemical parameters were lowered and significantly different (P*0.01), when compared with the disease control.
Conclusion: It can be concluded that 70% EEEL imparted a protective action against adrenaline induced hypertension in rats.
Keywords
- Umang J H, Tejas G H, Tusharbindu D R, Pravin T R. Evaluation of antihypertensive activity of Evolvulus alsinoides in adrenaline induce hypertensive rats. Int J Pharm Pharm Sci. 2012; 4(4): 194-198.
- Enyioma O N. Management of hypertension. Bulletin of the Kuwait Institute for medical specialization 2003; 2:73-82.
- Doggrell S A, Brown L. Rat models of hypertension cardiac hypertrophy and failure cardiovascular Research.1998; 39: 89-105.
- Bernatova I, Pechanova O, Pelouch V, Simko F. Regression of chronic L-NAME treatmentinduced left ventricular hypertrophy effect of Captopril. J Mol Cell Cardiol.2000; 32:177-185.
- Hropot M, Langer K H, Wiemer G, Grotsch H, Linz W. Angiotensin II subtype ATI receptor blockade prevents hypertension and renal insufficiency induced by chronic NO synthase inhibition in rats. Naunyn Schmiedebergs. Arch. Pharmacol.2003; 367: 312-317.
- Perry L M, Metzger J. Medicinal Plants of S E Asia attributed properties and uses. Cambridge Massachusetts and London. The MIT Press.1980:23-148.
- Gilani A H, Aftab K, Suria A, Siddiqui S, Salem R, Siddiqui B, Faizi S. Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytotherapy research.1984; 8(2): 7-91.
- Gillman A G, Rall T W, Nies A, Taylor P Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 8th edition, Pergamon Press, New York.1990(1&2):749806.
- Iemitsu M, Miyauchi T, Maeda S, Sakai S, Fujii N, Miyazaki H et al. Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism. hypertens Res.2003; 26:10-25.
- Gokhale S B, Kokate C K, Purohit A P. The text book Pharmacognosy, 29th edition; 2009.
- Weishaar H D. The photometric determination of LDH. Med Welt: 1975; 26:387.
- Pagana K, Pagana T. Mosby’s Manual of diagnostics and laboratory tests.2006; 3:351-356.13. Grynberg A, Demaison L. Fatty Acid oxidation in the heart. J Cardiovasc. Pharmacol.1996; 28:11-17.
- Suzanne O, Amin Z M, David A C. Pathogenesis of hypertension. Ann Intern Med.2003;139:761-776.
- Spanuk M H. Biochemical and Physiological aspect of human nutrition. In: Carbohydrate metabolism synthesis and oxidation (McGrane M.M. Ed.) WB saunders Philadelphia.2000; 172-173.
- Groff J L, Gropper S S. Advanced nutrition and human metabolism. In: Carbohydrates wadsworth belmont C A.2000; 86-87.
- Groff J L, Gropper S S. Advanced nutrition and human metabolism. In: The Cell: A microscosm of life wadsworth Belmont.2000; 22-23.
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