Journal of Pharmaceutical Research

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A simple, specific and economic UV spectrophotometric method has been developed using as a solvent methanol:water (80:20) to determine the Nabumetone content in bulk and pharmaceutical dosage formulations. The quantitative determination of the drug has been carried out at a predetermined λmax of 270nm, it was proved linier in the range 2-12 μg/mL and exhibited good correlation coefficient (R2=0.997) and excellent mean recovery (98-100.09%). The method was validated statically and by recovery studies for linearity, precision, repeatability and reproducibility as per ICH guideline. The obtained results proved that the method can be employed for the routine analysis of Nabumetone in bulk as well as in the commercial formulations.   


Keywords

Nabumetone, UV Spectroscopy, Validation, Stress Studies.
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