Pharmacodynamics of Metformin in Detarium Gum Mucoadhesive Formulation

M. U. Adikwu; O. Okorie; A. A. Attama

Vol 3, No 3 (2004)
Pages: 54-56
Published: 2004-07-01

Pharmacodynamics of Metformin in Detarium Gum Mucoadhesive Formulation

M. U. Adikwu ¹, O. Okorie ², A. A. Attama ¹

Affiliations
1 Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria
2 Department of Pharmaceutical Technology & Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria

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The pharmacodynamic effects of metformin in a mucoadhesive delivery system of detarium gum are presented. The gum compacts alone without the drug showed blood glucose lowering capacity. The combinations showed marked antidiabetic effect in streptozotocin-induced diabetic rat models.