The Effect of Snail Mucin on the Ulcer Healing Rate of Clarithromycin

M. U. Adikwu; C. O. Okolie; A. A. Agboke

The Effect of Snail Mucin on the Ulcer Healing Rate of Clarithromycin

M. U. Adikwu ¹, C. O. Okolie ², A. A. Agboke ³

Affiliations
1 Department of Pharmaceutics, University of Nigeria, Nsukka 410 001, Nigeria
2 Department of Science Laboratory Technology, University of Nigeria, Nsukka 410 001, Nigeria
3 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria

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The effect of mucin on the ulcer-healing rate of clarithromycin has been investigated. The snail mucin extract was obtained from the giant African snail, Achatina achatina (Family Arionidae). The mucin was precipitated with acetone, collected and air-dried. Ulcers were induced with indomethacin in rats. The ulcer-healing rate was determined for clarithromycin alone, mucin alone and the combination of both. The control group did not receive any of the drugs.

The results showed that the healing rate of clarithromycin alone was less than the healing rate achieved with clarithromycin and mucin combinations. The healing rate increased with increasing concentration of mucin. It was also observed that the ulcer-healing rate of mucin alone was higher than the healing rate of clarithromycin alone.