Journal of Pharmaceutical Research

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A simple and precise HPLC method has been developed for simultaneous quantitation of lansoprazole and domperidone in pharmaceutical formulations. The chromatographic separation was achieved at ambient temperature using an Intersil C18 (4.6 × 250 mm, 10 μm) column using a mobile phase comprising of 0.1 M sodium acetate and acetonitrile (55: 45 v/v), pH adjusted to 7.0 with orthophosphoric acid. The retention times for lansoprazole and domperidone were 5.78 min and 3.77 min respectively. The mean recoveries from the capsule formulations were between 99-101%. The detector response was found to be linear in the concentration range of 24-36 μg/mL for lansoprazole and 8-12 μg/mL for domperidone. The developed method herein described can be employed for quality control and routine analysis of drugs in capsule formulation.

Keywords

Lansoprazole, Domperidone, Quantitation, RP-HPLC.
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