Evaluation of Rosin as a Cream Base for Topical Ketoconazole Preparation

The purpose of this investigation was to develop a ketoconazole cream with rosin for both topical and systemic delivery. Creams were prepared by using rosin as one of the components in different proportions with different cream base combinations. The drug excipients interaction studies were carried out and results revealed that there is no interaction between the drug and the excipients used in the formulation. The prepared creams were evaluated for their physicochemical properties, pH, viscosity, particle size, drug content and in vitro release studies. The release of the drug, ketoconazole was measured for eight hours and compared with a standard marketed formulation. The formulation (F8) fulfilled all topical formulation parameters; it can be used for the systemic topical drug delivery.