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Synthesis and Antimicrobial Activity of some 1, 4-Benzothiazine Derivatives
Equimolar quantity of 2-aminothiophenol and ethylchloroacetate was condensed and the solid mass obtained was refluxed. The compound obtained was refluxed with 4-aminoacetophenone to produce 3(4'-acetylphenylamino) 1,4-benzothiazine. The 3(4'-acetylphenylamino)1,4-benzothiazine was reacted with corresponding aldehyde to give 3[4'-(3"-substituted-2"-propenone-1"-yl) phenylamino]1,4-benzothiazine. The above synthesized compounds and guanidine nitrate were refluxed to afford 3[4'(2"-amino-4"- substituted-phenyl)-pyrimidine-4"yl)phenylamino]1,4-benzothiazine. The structures of the newly synthesized compounds were elucidated on the basis of elemental analysis, FTIR and 1H-NMR and have been screened for antimicrobial activity.
Keywords
1, 4-Benzothiazine, Spectral Analysis, Antibacterial, Antifungal.
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