Journal of Pharmaceutical Research

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The feasibility of formulating the solid dispersions of mefenamic acid into tablet dosage forms is evaluated. All the tablets formulated employing solid dispersions of mefenamic acid in superdisintegrants gave rapid and higher dissolution of mefenamic acid when compared to that of mefenamic acid plain tablets. The increasing order of dissolution rate of formulated tablets with various carriers was Croscarmellose (CC)>Pregelatinised starch (PGS) > Primojel(PJ) > Crospovidone (CP). The same order of performance was observed with tablets formulated employing superdisintegrants alone and in combination with PVP.A 2.75 fold increase in the dissolution rate of mefenamic acid was observed with tablets formulated employing its solid dispersions in CC (MAF4) when compared to plain tablets (MAF1). A 6.97 fold increase in the dissolution rate of mefenamic acid was observed with tablets formulated employing its solid dispersions in combined carriers CC and PVP (MAF8) when compared to its plain tablets (MAF1).

Keywords

Mefenamic Acid, Solid Dispersion, Dissolution Rate, Solubility, Polyvinylpyrrolidine, Pregelatinised Starch.
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