Journal of Pharmaceutical Research

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Methanol extract of the stem of Clerodendrum phlomidis L. was investigated for anti-hepatotoxic activity against CCl4 induced hepatic damage in male Wister rats. The extracts in dose of 500mg/kg b.w p.o for 7 days were compared with the standard silymarin (Silybon-70, 10mg/kg-b.w p.o). The methanol extract of the plant have shown anti-hepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 29.88 %, serum glutamate pyruvate transaminase (SGPT) by 25.86%while alkaline phosphatase (ALP) 14.21 %. On the other hand, total protein (TP) were increased by 27.20 %, as compared to standard drug silymarin which decreased SGOT by 49.66 %, SGPT by 50.31 %,ALKP by 33.29%and increased TP levels by 49.40 %. These biochemical observations were also supplemented by histopathological examinations of the liver sections.

Keywords

Antihepatotoxic, Carbon tetrachloride, Clerodendrum phlomidis, Silymarin.
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