Journal of Pharmaceutical Research

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Solanum surattense Linn is found in the tribal area of Koraput district and extensively used traditionally by the tribal people as anthelmintic, diuretic, antiarrhythmic, hypotensive, expectorant and carminative. The present study is an attempt to explore the anthelmintic activity of ethanolic extract of fruits of plant Solanum surattense. Thin Layer Chromatography study was done to confirm whether the bioactive fraction or single constituent of plant crude extract is showing anthelmintic activity. The various doses of ethanolic extracts were evaluated for their anthelmintic activities on adult Indian earthworms, Pheretima postuma. All extracts were able to show anthelmintic activity at 10 mg/ml concentration. The activities are comparable with the standard drugs, Piperazine citrate and Albendazole. All the doses of ethanolic extract of Solanum surattense showed better anthelmintic activity than the standard drugs. When the dose of the extract was increased, a gradual increase in anthelmintic activity was observed. The data were found statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05).

Keywords

Solanum surattense, Solanaceae, Anthelmintic, Piperazine Citrate, Albindazole.
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