Synthesis and Antimicrobial Activity of some Substituted Novel Thiazolidine-4-One Derivatives

The reaction of l-Proline with hydrazine hydrate (99%) in the presence of conc. sulfuric acid gave pyrrolidine- 2-carbohydrazide (I). The reaction was carried out by both conventional and microwave method. Compound I on treatment with substituted aromatic aldehydes furnished the corresponding schiff's bases (1a-10a), which on further reaction with mercaptoacetic acid yielded N-(4'-Oxo-2'-substituted phenylthiazolidin-3'- yl)pyrrolidine-2-carboxamide (1b-10b). The structures of these compounds were confirmed by UV, FTIR, ¹H NMR, ESI-mass spectra and elemental analysis. All the synthesized compounds were screened for antimicrobial activity against variety of bacterial and fungal strains. The compounds 3b, 6b and 8b showed maximum antibacterial activity against B.subtilis and S.aureus, 2b and 10b against E.coli and P.aeruginosa and compounds 3b, 7b and 8b showed the maximum antifungal activity against C. albicans and A. niger.