Formulation and Evaluation of Gel of Dimethyl Disulfide-Silver Complex

During the past several years a number of complexes of transition metals have been reported in which the central metal ions have been coordinated by aromatic or unsaturated compounds containing sulfur donor atoms. Dimethyldisulphide which has been reported to possess antibacterial, as well as antifungal activity is one of the main constituents of Allium sativum (Garlic). In the present study dimethyldisulphide has been complexed with silver metal. The complex so formed has been characterized by spectroscopic methods, further the complex has been formulated into a gel. Different gels were prepared with varying concentration of Carbopol 934. Minimum inhibitory concentration (MIC) was calculated using cup-plate method. Gels were further evaluated for physical properties like color, pH, spreadability, consistency, diffusion, stability and viscosity. Evaluation of gel was further done against Staphylococcus aureus (ATCC 6538), and Pseudomonas aeruginosa (ATCC 9027). The gel showed promising antibacterial activity against microorganisms used for study. The Gel was stable at room temperature.