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formulation Development and Evaluation of Fast Dissolving Tablets of Telmisartan
Present investigation was undertaken with a view to develop fast dissolving tablets of Telmisartan which offers a new range of product having desired characteristics and intended benefits. Fast dissolving tablets of Telmisartan using various superdisintegrants such as Sodium Starch Glycolate (SSG), Crosspovidone (CP) and Crosscarmellose sodium (CCS) were formulated by direct compression method and evaluated for physicochemical parameters, content uniformity, in vitro release and stability studies. All the formulation batches showed drug release in the range of 98.6% - 100.6% within 20 min. Disintegration time of all batches was less than 1 min. The best formulation F6 containing 5% CP and 2.5% α-cyclodextrin exhibited 98.8% drug release within 15 min and disintegration time of 13 sec. The formulation F6 was found to be stable at accelerated conditions of temperature and humidity (40°C and 75% RH). Fast dissolving tablets containing crosspovidone (5%) was found to give best results for in vitro disintegration and dissolution. Moreover, addition of α-cyclodextrin (2.5% w/w) might have enhanced swelling of tablet, thereby decreasing the disintegration time and increased wettability and dispersability of tablets leading to improved dissolution.
Keywords
Crosscarmellose Sodium, Crosspovidone, Sodium Starch Glycolate, α-Cyclodextrin, Direct Compression.
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