Dissolution Rate Enhancement, in Vitro Evaluation and Investigation of Drug Release Kinetics of Flurbiprofen Solid Dispersion

In the present research work dissolution rate enhancement efficiency, solid dispersion formation ability of hydrophilic polymers and investigation of drug release kinetics of Flurbiprofen was studied. The hybrid method of fusion-solvent and solvent evaporation was employed to prepare solid dispersion. PEG 6000 and PVP K-30 was used as hydrophilic polymers to improve the solubility, dissolution of Flurbiprofen, and evaluated for flow properties. Physicochemical characterizations of solid dispersions were carried out by FT-IR, XRD and DSC. FTIR study did not show any chemical modification or complexation in solid dispersion. This indicates that there is a physical interaction between the drug and carriers, and increase in the solubility is due to surface modification. Diffuse XRD pattern shows that the drug remains in the amorphous form in solid dispersion. The solubility and dissolution study shows marked increase in solid dispersion than the physical mixtures. The reason for increase in solubility and dissolution rate is increased surface area due to reduction in crystallinity and increased wetting of drug molecules. It may be concluded from the DSC, XRD and FT-IR study that the drug is dispersed homogenously in carrier in amorphous form and does not interact chemically with the carrier. Hydrophilic polymers were found to increase the solubility of Flurbiprofen.