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Evaluation of Modified Borg Dyspnoea Score and 6-Minute Walk Test in Pulmonaryarterial Hypertensionpatients Recievingphosphodiesterase Inhibitors
Methodology: A prospective open label randomized study was conducted over a period of 8 months in hospitalized patients who visited the in- patient block in a tertiary care hospital in Nilgris. Simple Randomization technique was adopted to allocate the patients into three studygroups. At the baseline Visit, Modified Borg Dyspnea Scale (MBDS) and 6 MWT(6 Minute Walk Test) were evaluated to confirm study criteria and were allotted into 3 doses based on their severity upon Right Ventricular Systolic Pressure. The same parameters were assessed on each visit for all the patients throughout thestudy period.
Results and Discussion: In our study, Sildenafil Citrate showed an improvement in MBDS and 6 MWT after 8 months of therapy which were assessed using Kruskal-Wallis non-parametric test. A remarkable improvement in6MWT from 171.88±52.4 metres to 337.12±71.84 metres was observed. There was an improvement in dyspnea by Borg scale in all study groups. Cor-pulmonale patients were more benefited (p<0.001) whereas patients with Atrial Septal Defect (ASD) and Rheumatic Heart Disease (RHD) also improved significantly (p<0.05).
Conclusion: Sildenafil has been reported to be welltolerated among the patient population. The patients who were slightly affected at baseline with moderate to severe dyspnoea became slight grade which.
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