Journal of Pharmaceutical Research

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A Profile of Paclitaxel


Affiliations
1 Subramanium College of Science and Technolgy, Holambi Khurd, New Delhi -110 082, India
2 Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi -110 062, India
3 Department of Pharmacy, Banasthali University, Banasthali Vidyapeeth, Rajasthan-304 022, India
 

Treatment of cancer is a challenge to physicians, and it requires multiple treatments. But the role of paclitaxel cannot be neglected in cancer treatment. It is the most promising anti tumour agent. As the drug has poor water solubility, number of alternative controlled release formulations has been developed having variety of dose regimens to overrule the limitations of cremophor based formulation. More advanced Drug delivery systems includes Nanoparticles, Microemulsion, Liposomes, Oncogel, Microspheres, Cyclodextrin complex, etc. Also the drug has flexible structural aspects hence lots of modifications are possible in the structure.

Keywords

Paclitaxel, Cremophor, Nanoparticles, Formulations.
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  • A Profile of Paclitaxel

Abstract Views: 342  |  PDF Views: 98

Authors

S. Siddiqui
Subramanium College of Science and Technolgy, Holambi Khurd, New Delhi -110 082, India
S. Kumar
Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi -110 062, India
A. A. Siddiqui
Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi -110 062, India
S. Kataria
Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi -110 062, India
S. Paliwal
Department of Pharmacy, Banasthali University, Banasthali Vidyapeeth, Rajasthan-304 022, India

Abstract


Treatment of cancer is a challenge to physicians, and it requires multiple treatments. But the role of paclitaxel cannot be neglected in cancer treatment. It is the most promising anti tumour agent. As the drug has poor water solubility, number of alternative controlled release formulations has been developed having variety of dose regimens to overrule the limitations of cremophor based formulation. More advanced Drug delivery systems includes Nanoparticles, Microemulsion, Liposomes, Oncogel, Microspheres, Cyclodextrin complex, etc. Also the drug has flexible structural aspects hence lots of modifications are possible in the structure.

Keywords


Paclitaxel, Cremophor, Nanoparticles, Formulations.