Journal of Pharmaceutical Research

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A study was carried out using LC-MASS Spectroscopy to determine the degradation products of formulation (capsules) containing Amoxicillin and Dicloxacillin. Previously an RP-HPLC method was performed to determine the stability of five batches of four different brands of formulation (capsules) containing Amoxicillin and Dicloxacillin which were expiring in consecutive months (7th, 8th, 9th, 10th and 12th month of 2010). The Dicloxacillin content in all the five batches steadily decreased over the period of consecutive 5 month Assays (one month interval between each Assays), thereby determined the degradation product of Dicloxacillin by LC-MASS Spectroscopy.

Keywords

LC-MASS Spectroscopy, RP-HPLC, Amoxicillin, Dicloxacillin, Degradation Product.
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