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Antimicrobial Study (Invitro) of Azomethines of Aryl Oxazoles


Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, India
 

A novel series of azomethines of aryl oxazoles were synthesised and investigated for their antimicrobial activity against Gram positive and Gram negative bacteria using antibiotic diffusion method. The recorded data of zone of inhibition showed significant broad activity when compared with standard. The sensitivity of the Gram positive bacteria to the tested compounds was higher than that of Gram negative bacteria. The synthesised compounds were also screened for antifungal activity and observed that they had an inhibitory effect against the pathogenic fungi.

Keywords

Oxazoles, Azomethines, Antibacterial Activity, Antifungal Activity.
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  • Antimicrobial Study (Invitro) of Azomethines of Aryl Oxazoles

Abstract Views: 220  |  PDF Views: 86

Authors

V. Niraimathi
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, India
A. Jerad Suresh
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, India
Lata Sriram
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, India
T. Latha
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, India

Abstract


A novel series of azomethines of aryl oxazoles were synthesised and investigated for their antimicrobial activity against Gram positive and Gram negative bacteria using antibiotic diffusion method. The recorded data of zone of inhibition showed significant broad activity when compared with standard. The sensitivity of the Gram positive bacteria to the tested compounds was higher than that of Gram negative bacteria. The synthesised compounds were also screened for antifungal activity and observed that they had an inhibitory effect against the pathogenic fungi.

Keywords


Oxazoles, Azomethines, Antibacterial Activity, Antifungal Activity.