Cell Adhesion on Non-Biological Surfaces

Interaction of blood components with an artificial surface is very complex depending upon the conformational variations of the specific cell receptor sites as they approach to the surfabef.2-3. 'Various biological sequencesa are followed based on the nature of the contacting surface such as surface charge, surface energy, flow condition (and other physicochemical aspects. In brief when any material comes in contact with blood, it is immehiately altelc ed by the adsorption of .plasma protein and the nature of the protein adsorbed depend greatly upon the physicochemical properties of the material surface. It is observed3 that surfaces adsorbing albumin preferentially adhere less, platelets compared to other glycoproteins such as'y-Globulin and fibrinogen etc. Beside this bioiogical process of adherance of platelets it is also found2 that hydropbilic surfaces adhere more platelet compared to hydrophobic surfaces.