Journal of Surface Science and Technology

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Surface Properties of Amphiphilic Drugs in Presence of Cationic Surfactants


Affiliations
1 School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.), India
2 Department of Chemistry, Birla Institute of Technology and Science, Pilani-333 031, Rajasthan, India
     

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Surface properties of two amphiphilic drugs i.e. amitriptyline and imipramine have been studied in the absence and presence of some cationic surfactants i.e. alkyltriphenylphosphonium bromide [R = 16 (CTPB), R = 14 (TTPB)] and alkyldiethylcthanolammonium bromide [R = 16 (CDEEAB), R = 14 (TDEEAB)] by surface tension measurement at 300 K. The critical micelle concentration (CMC), maximum surface excess concentration at the air/water interface (Γmax), minimum area per surfactant molecule at the air-water interface (Amin) and the surface pressure at the CMC (πCMC) have been determined. Γmax value increases and CMC/πCMC decrease & with an increasing mole fraction of surfactants. The solubility of amphiphilic drugs in cationic surfactant systems has also been studied.

Keywords

Amphiphilic Drug, Additives, Cationic Surfactant, Surface Properties, Surface Tension.
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  • Surface Properties of Amphiphilic Drugs in Presence of Cationic Surfactants

Abstract Views: 213  |  PDF Views: 2

Authors

Toshikee Yadav
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.), India
Deepti Tikariha
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.), India
Jyotsna Lakra
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.), India
Amit K. Tiwari
Department of Chemistry, Birla Institute of Technology and Science, Pilani-333 031, Rajasthan, India
Subit K. Saha
Department of Chemistry, Birla Institute of Technology and Science, Pilani-333 031, Rajasthan, India
Kallol K. Ghosh
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 (C.G.), India

Abstract


Surface properties of two amphiphilic drugs i.e. amitriptyline and imipramine have been studied in the absence and presence of some cationic surfactants i.e. alkyltriphenylphosphonium bromide [R = 16 (CTPB), R = 14 (TTPB)] and alkyldiethylcthanolammonium bromide [R = 16 (CDEEAB), R = 14 (TDEEAB)] by surface tension measurement at 300 K. The critical micelle concentration (CMC), maximum surface excess concentration at the air/water interface (Γmax), minimum area per surfactant molecule at the air-water interface (Amin) and the surface pressure at the CMC (πCMC) have been determined. Γmax value increases and CMC/πCMC decrease & with an increasing mole fraction of surfactants. The solubility of amphiphilic drugs in cationic surfactant systems has also been studied.

Keywords


Amphiphilic Drug, Additives, Cationic Surfactant, Surface Properties, Surface Tension.