Modulating Effects of Curcumin on Chromium Induced Chromosomal Aberrations in Somatic Cells of Mice

The protective effects of curcumin in chromium induced cytotoxicity was evaluated in in vivo animal model using analysis of chromosomal aberrations in somatic cells of mice. Three doses of curcumin were selected for modulation and given to animals after priming with chromium. The animals ware sacrificed 48hr after the treatment and slides were prepared. A significant decrease was observed in the percentage of chromosomal aberrations when animals were primed with curcumin. The present results clearly indicate the protective nature of curcumin against heavy metal genotoxicity.