Research Journal of Pharmaceutical Dosage Form and Technology

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A Review:Pulsatile Drug Delivery System


Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
     

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Pulsatile drug delivery system are gaining a lot of importance as these system deliver the drug at specific time as per the pathophysiological need of disease ,resulting in improved patient compliance and therapeutic efficiency. Disease where in PDDS are promising include asthama, peptic ulcer, arthritis, cardio vascular disease, peptic ulcer, attention deficit syndrome in children and hypercholesteromia. PDDS can be classified in time controlled system where the drug controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, like the ph or enzyme present in the intestinal tract or enzyme present in drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electric effect and irradiation. The current article focuses on the disease requiring PDDS, methodologies involved for the existing system, recent update and PDDS product currently available in the market.
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  • A Review:Pulsatile Drug Delivery System

Abstract Views: 249  |  PDF Views: 1

Authors

Amit A. Dhengale
Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
Avinash B. Darekar
Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
R. B. Saudagar
Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

Abstract


Pulsatile drug delivery system are gaining a lot of importance as these system deliver the drug at specific time as per the pathophysiological need of disease ,resulting in improved patient compliance and therapeutic efficiency. Disease where in PDDS are promising include asthama, peptic ulcer, arthritis, cardio vascular disease, peptic ulcer, attention deficit syndrome in children and hypercholesteromia. PDDS can be classified in time controlled system where the drug controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, like the ph or enzyme present in the intestinal tract or enzyme present in drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electric effect and irradiation. The current article focuses on the disease requiring PDDS, methodologies involved for the existing system, recent update and PDDS product currently available in the market.