Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation and Evaluation of Aqueous Enteric Coated Delayed Release Omeprazole Pellets


Affiliations
1 Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, India
2 Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, India
     

   Subscribe/Renew Journal


The main objective of the present study was to develop and optimize enteric coated pellets of Omeprazole using enteric polymers like hydroxyl propylmethylcellulose phthalate. Characterization of the drug was carried out by performing the melting point, identification test by FTIR, solubility, loss on drying and assay parameteres. Then drug-excipient interaction studies were carried out using FTIR. Six formulations of pellets were prepared, from which F5 was chosen for further coating process. Then F5 formulation was sub-coated with HPMC E5 and enteric coated using HPMCP-55.All the formulations were evaluated for their physico-chemical parameters like assay, drug content and dissolution, etc. The in vitro drug release study was performed for the prepared formulations. From the in vitro drug release study, it was found that all the formulations demonstrated excellent physical resistance to the acid medium after 2 hour and the drug release was found to be within specified limits. Formulation subjected to stability studies were checked for physical appearance, drug content and dissolution for 3 months.

Keywords

Aqueous Enteric Coated, Delayed Release Omeprazole Pellets.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 287

PDF Views: 0




  • Formulation and Evaluation of Aqueous Enteric Coated Delayed Release Omeprazole Pellets

Abstract Views: 287  |  PDF Views: 0

Authors

Viswanadham Manasa
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, India
K. Vanitha
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, India
M. Venkataswamy
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, India
P. Prabhakar
Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, India
Alluri Ramesh
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, India

Abstract


The main objective of the present study was to develop and optimize enteric coated pellets of Omeprazole using enteric polymers like hydroxyl propylmethylcellulose phthalate. Characterization of the drug was carried out by performing the melting point, identification test by FTIR, solubility, loss on drying and assay parameteres. Then drug-excipient interaction studies were carried out using FTIR. Six formulations of pellets were prepared, from which F5 was chosen for further coating process. Then F5 formulation was sub-coated with HPMC E5 and enteric coated using HPMCP-55.All the formulations were evaluated for their physico-chemical parameters like assay, drug content and dissolution, etc. The in vitro drug release study was performed for the prepared formulations. From the in vitro drug release study, it was found that all the formulations demonstrated excellent physical resistance to the acid medium after 2 hour and the drug release was found to be within specified limits. Formulation subjected to stability studies were checked for physical appearance, drug content and dissolution for 3 months.

Keywords


Aqueous Enteric Coated, Delayed Release Omeprazole Pellets.