In- Situ Nasal Gel Drug Delivery: An Overview

Intranasal Therapy has been an accepted form of treatment in the Ayurvedic system of Indian medicine. The nasal delivery is a feasible alternative to oral or parenteral administration for some drug because of the high permeability of the nasal epithelium , rapid drug absorption across this membrane and avoidance of first pass metabolism. Prolonged drug delivery can be achieved by various new dosage forms like in situ gel. In situ forming polymeric formulation are drug delivery system that is in sol form before administration in the body , but once administered , undergoes gelation in situ to form a gel. In situ nasal drug delivery system is the type of mucoadhesive drug delivery system. In situ nasal gel drug delivery system is advantageous over the conventional drug delivery system like sustained and prolonged release of drug , reduced frequency of administration. Thus this review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal absorption mechanism, and In- situ nasal gel evaluation.