Formulation Development and Evaluation of Floating Drug Delivery System for Proton Pump Inhibitors (Lansoprazole)

The present study has been a satisfactory attempt, to formulate and evaluate floating tablet of Lansoprazole with a view of improving bioavailability and giving a controlled release of a drug. Floating tablet of Lansoprazole will reduce the frequency of administration of drug and helps to minimize dose of drug and side effects associated with the drug. Lansoprazole Floating Drug Delivery systems can be prepared by wet granulation method using HPMCK4M: Eudragit-RL100 polymer ratio and PVPK-30 as a binder, Sodium-bi-Carbonate: Citric acid as gas generating agent. The given floating tablet of Lansoprazole was made to prepare with different polymer combination such as Eudragit-RL100: HPMCK4M and varying concentration of HPMCK4M, PVPK30. Comparing the all formulations, Floating drug delivery system formulation of F5 was considered as an ideal formulation which exhibited 99.26% of drug release in 8 hours, and floating lag time of 11seconds with a total floating time of 12 hours.