Formulation, Evaluation of Clotrimazole Vaginal Suppository

The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository with anti-microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppository and evaluation of suppository. In the present research a successful attempt to formulate a suppository by fusion method and the various evaluation parameters was done. The microbial test against the causative agents was performed. Finally the stability of the formulation was checked. The inhibitory action of the Clotrimazole suppository was satisfactorily. The methods of its evaluation developed in this research work may be beneficial in preventing bacterial vaginosis. Further investigations have to be carried out in antimicrobial activity in the bacterial viginosis treatment is needed.