Formulation and Evaluation of Sustained Release Matrix Tablet of Mefenamic Acid

The main objective of the present work was to develop sustained release matrix Tablets of Mefenamic acid. To reduce the frequency of administration and to improve the patient compliance, a once daily sustained release formulation of Mefenamic acid is desirable. So sustained release Matrix Tablet of Mefenamic acid was designed by using Hydroxy Propyl Methyl Cellulose (HPMC).Varying ratios of drug and polymer were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by Single polymer. The granules were prepared by wet granulation method. After evaluation of physical properties like Weight variation, Hardness, Thickness, Friability of tablet, the different formulations checked for the Percentage Drug content which having good uniformity. The in vitro release study was performed in phosphate buffer pH 7.4 up to 12 hrs. The effect of polymer concentration was studied. Dissolution data was analyzed by Percentage cumulative drug release. Matrix tablets studied for the different polymer ratios and performance checked for different concentration ratios. The results of drug dissolution studies showed improved drug release, retardation effects of the polymers and could achieve better performance. It was observed that matrix tablets contained polymer blend of HPMC were successfully sustained the release of drug up to 12 hrs.