Research Journal of Pharmaceutical Dosage Form and Technology

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Synthesis of Chalcones and Evaluation of Their Anti-Microbial Activity


Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, India
2 University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur-500510, India
     

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Chalcones are main precursor for biosynthesis of flavonoids which are frequent components of human diet. Recent studies on biological evaluation of chalcones revealed some Anticancer, Anti inflammatory, Anti mitotic, Anti tubercular, Cardiovascular, cell differenciation inducing, nitric oxide regulation modulatory and hyperglycaemic activities. This present research includes synthesis of varies chalcones from 5-acetyl salicylamide and evaluation of their anti microbial activity. Objective:

1. To synthesize chalcones using different catalyst solid NaOH.

2. Characterize chalcones using TLC, NMR, MASS and IR spectrometry.

3. To evaluate the anti-microbial activity .


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  • Synthesis of Chalcones and Evaluation of Their Anti-Microbial Activity

Abstract Views: 225  |  PDF Views: 0

Authors

P. Parveen
Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, India
P. Usha
Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, India
V. Vasu Naik
Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, India
Sk. Shaheda Sultana
Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, India
M. Gayatri Ramya
University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur-500510, India

Abstract


Chalcones are main precursor for biosynthesis of flavonoids which are frequent components of human diet. Recent studies on biological evaluation of chalcones revealed some Anticancer, Anti inflammatory, Anti mitotic, Anti tubercular, Cardiovascular, cell differenciation inducing, nitric oxide regulation modulatory and hyperglycaemic activities. This present research includes synthesis of varies chalcones from 5-acetyl salicylamide and evaluation of their anti microbial activity. Objective:

1. To synthesize chalcones using different catalyst solid NaOH.

2. Characterize chalcones using TLC, NMR, MASS and IR spectrometry.

3. To evaluate the anti-microbial activity .