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Formulation and In-Vitro Characterization of Ketorolac Tromethamine Ophthalmic Inserts


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1 SCSSS's Sitabai Thite College of Pharmacy, Shirur. Pune- 412210, India
     

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Ophthalmic inserts are sterile, solid preparations containing drug as dispersion or as solution in the polymeric support. Ketorolac Tromethamine is a nonsteroidal anti- inflammatory drug (NSAID) has a pronounced analgesic, antipyretic and anti-inflammatory action. It is a pyrrole derivative and very effective against disorders of eye. In this study, ophthalmic inserts of Ketorolac Tromethamine were prepared using polymers such as Hydroxypropyl methyl cellulose (HPMC) and Methyl cellulose (MC), and plasticizer such as Polyethylene glycol 400 (PEG) by solvent casting method. The ophthalmic inserts were evaluated for uniformity of thickness, weight, drug content and swelling index. In vitro drug release studies of formulated ocuserts were performed by studying the diffusion through the artificial membrane (prehydrated cellophane). IR spectral studies were performed to confirm the interaction of drug in formulation using KBr disc method. Out of eight formulations prepared, the formulation containing HPMC (1:2) showed complete and prolonged release with 99.91% at the end of 7 hrs.

Keywords

Ketorolac Tromethamine, Ophthalmic Inserts, HPMC, MC, In-vitro Release.
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  • Formulation and In-Vitro Characterization of Ketorolac Tromethamine Ophthalmic Inserts

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Authors

Sachin N. Kothawade
SCSSS's Sitabai Thite College of Pharmacy, Shirur. Pune- 412210, India
S. T. Deshpande
SCSSS's Sitabai Thite College of Pharmacy, Shirur. Pune- 412210, India
A. S. Lunkad
SCSSS's Sitabai Thite College of Pharmacy, Shirur. Pune- 412210, India
P. A. Dighe
SCSSS's Sitabai Thite College of Pharmacy, Shirur. Pune- 412210, India

Abstract


Ophthalmic inserts are sterile, solid preparations containing drug as dispersion or as solution in the polymeric support. Ketorolac Tromethamine is a nonsteroidal anti- inflammatory drug (NSAID) has a pronounced analgesic, antipyretic and anti-inflammatory action. It is a pyrrole derivative and very effective against disorders of eye. In this study, ophthalmic inserts of Ketorolac Tromethamine were prepared using polymers such as Hydroxypropyl methyl cellulose (HPMC) and Methyl cellulose (MC), and plasticizer such as Polyethylene glycol 400 (PEG) by solvent casting method. The ophthalmic inserts were evaluated for uniformity of thickness, weight, drug content and swelling index. In vitro drug release studies of formulated ocuserts were performed by studying the diffusion through the artificial membrane (prehydrated cellophane). IR spectral studies were performed to confirm the interaction of drug in formulation using KBr disc method. Out of eight formulations prepared, the formulation containing HPMC (1:2) showed complete and prolonged release with 99.91% at the end of 7 hrs.

Keywords


Ketorolac Tromethamine, Ophthalmic Inserts, HPMC, MC, In-vitro Release.