Formulation and Evaluation of Fast Dissolving Tablets of Cefixime Trihydrate

Fast Dissolving Tablet instead of dissolving or disintegrating in water is expected to dissolve or disintegrate in oral cavity without drinking water. Super disintegrates are added to a drug formulation to facilitate the break-up or disintegration of tablet or capsule content into smaller particles that can dissolve more rapidly than in the absence of disintegrates In the present study, the effects of a natural superdisintegrants Plantago ovata, Hibiscus rosa sinensis and synthetic superdisintegrants like sodium starch glycolate (SSG), Crosspovidone and Croscarmellose sodium (Ac-di-sol) were compared in the formulations of fast dissolving tablets (FDT). FDTs of Cefixime were prepared by direct compression method and were evaluated for weight variation, hardness, thickness, disintegration time, wetting time, water absorption ratio, In vitro dispersion, friability and dissolution. Among all the super disintegrates, Plantago ovata showed the highest swelling index and natural super disintegrates like husk of Plantago ovata showed better disintegrating property than the most widely used synthetic super disintegrates like AC-di-Sol, C.P and SSG in the formulations.