Research Journal of Pharmaceutical Dosage Form and Technology

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Pulsatile Drug Delivery System:Drugs used in the Pulsatile Formulations


Affiliations
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P., India
2 Department of Pharmaceutics, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P., India
3 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P, India
     

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Pulsatile drug delivery systems are developed to deliver drug in a programmed manner according to circadian behavior of diseases resulting in improved therapeutic efficacy as well as patient compliance These systems are designed for diseases showing chronopharmacological behavior and where the drug dose is required for extended day time or night time activity or for the drugs having high first pass effect or having site specific absorption in GIT, or for drugs with high risk of toxicity. Diseases wherein Pulsatile drug delivery system are likely to be successful for diseases such as asthma, peptic ulcer, cardiovascular diseases, arthritis, hypertension, and hypercholesterolemia. The current article focuses on the review of literature concerning the disease requiring Pulsatile drug delivery system and the drugs used in the pulsatile formulations to target diseases.
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  • Pulsatile Drug Delivery System:Drugs used in the Pulsatile Formulations

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Authors

Haribansh Narayan Singh
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P., India
Shivangi Saxena
Department of Pharmaceutics, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P., India
Sunil Singh
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P, India
Ajit Kumar Yadav
Department of Pharmaceutics, Invertis Institute of Pharmacy, Invertis University, Bareilly, U.P., India

Abstract


Pulsatile drug delivery systems are developed to deliver drug in a programmed manner according to circadian behavior of diseases resulting in improved therapeutic efficacy as well as patient compliance These systems are designed for diseases showing chronopharmacological behavior and where the drug dose is required for extended day time or night time activity or for the drugs having high first pass effect or having site specific absorption in GIT, or for drugs with high risk of toxicity. Diseases wherein Pulsatile drug delivery system are likely to be successful for diseases such as asthma, peptic ulcer, cardiovascular diseases, arthritis, hypertension, and hypercholesterolemia. The current article focuses on the review of literature concerning the disease requiring Pulsatile drug delivery system and the drugs used in the pulsatile formulations to target diseases.