Effect of pH on Dissolution Profile of Atenolol Sustained Release Matrix Tablets

The present study was performed to illustrate the effect of pH on dissolution profile of atenolol sustained release matrix tablets. Atenolol is -1 cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension. The drug is insoluble in water and has half-life of six to eight hours with oral bioavailability of 50% due to smaller dose of drug (less than 50 mg). Once daily Sustained release matrix tablets of Atenolol reduces the frequency of administration and improves the patient compliance. Atenolol matrices were prepared from combination of polymers HPMCK4M and HPMCK15M to sustain the release of the drug. Multimedia dissolution studies were performed to mimic the in-vivo condition by doing in-vitro test and pH/buffer selection is based on the exposure of drug from stomach to intestine/colon and to ensure the impact of pH changes on dissolution and release of drug substance for absorption. The study ensures the impact of pH changes on dissolution and release of drug substance for absorption.