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Transdermal Drug Delivery System:A Review


Affiliations
1 Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, India
2 SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune–412 210, India
3 Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk.), Pune – 411 048, India
     

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Transdermal therapeutic systems, or transdermal patches, facilitate controlled release of active ingredients through the skin and into the systemic circulation. Drugs administered through such systems escape first pass metabolism and steady state is maintained similar to a continuous intravenous infusion for up to several days. The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. This article gives a brief overview over principles behind transdermal drug delivery, as well as the advantages and disadvantages of transdermal therapeutic systems and the recent innovations in the field of transdermal drug delivery and also describes the methods of preparation of different types of transdermal patches, evaluation parameters and some available marketed products.

Keywords

Transdermal Drug Delivery System, Transdermal Patches, Evaluation of Transdermal System, Skin.
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  • Transdermal Drug Delivery System:A Review

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Authors

Bhakti R. Chorghe
Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, India
Swapnil T. Deshpande
SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune–412 210, India
Rohit D. Shah
Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, India
Swati S. Korabu
Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, India
Sagar V. Motarwar
Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk.), Pune – 411 048, India

Abstract


Transdermal therapeutic systems, or transdermal patches, facilitate controlled release of active ingredients through the skin and into the systemic circulation. Drugs administered through such systems escape first pass metabolism and steady state is maintained similar to a continuous intravenous infusion for up to several days. The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. This article gives a brief overview over principles behind transdermal drug delivery, as well as the advantages and disadvantages of transdermal therapeutic systems and the recent innovations in the field of transdermal drug delivery and also describes the methods of preparation of different types of transdermal patches, evaluation parameters and some available marketed products.

Keywords


Transdermal Drug Delivery System, Transdermal Patches, Evaluation of Transdermal System, Skin.