Transdermal Drug Delivery System: A Review

Today about 74% of drugs are taken orally and are found not be as effective as desired. To improve such characters transdermal drug delivery system was emerged. Drug delivery through the skin to achieve a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery system (TDDS) is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin effective medium from which absorption of the drug takes place and enters into circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved effective because of its large advantages over other controlled drug delivery systems. The main disadvantages to transdermal delivery systems stems from the fact that the skin is a very effective barrier; as a result, only medications whose molecules are small enough to penetrate the skin can be delivered in the method. A wide variety of pharmaceuticals are now available in transdermal patch form.