Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation and In Vitro Assessment of Controlled Release Matrix Tablets of Abacavir


Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
2 Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
     

   Subscribe/Renew Journal


The main objective of the present work was to develop controlled release matrix tablets of abacavir using different polymers namely hydroxy propyl methyl cellulose (HPMC), polyethylene oxide, pharmatose DCL 21, microcrystalline cellulose. Varying ratios of drug and polymer were selected for the study. The tablets were prepared by direct compression and wet granulation method. After evaluation of physical properties of tablet like hardness, friability, thickness, weight variation, the in vitro release study was performed by using USP type 1 dissolution apparatus in pH 6.8 phosphate buffer for 14 h. The effect of polymer concentration and polymer blend concentration were also studied. Release kinetics of abacavir matrix tablets were done by zero order, first order, higuchian square ischolar_main studies. The matrix tablets prepared with combination of HPMC K 100 M and PEO, showed slower release pattern when compared the matrix tablets prepared with HPMC K 100 M alone is clear indication of the drug release over a prolonged period. The DSC and FTIR study revealed that there was no chemical interaction between drug and excipients.

Keywords

Abacavir, HPMC, Polyox, Pharmatose, Aerosil, Controlled Release.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 235

PDF Views: 0




  • Formulation and In Vitro Assessment of Controlled Release Matrix Tablets of Abacavir

Abstract Views: 235  |  PDF Views: 0

Authors

D. Varun
Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
B. V. P. Deepthi
Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
P. V. Ayodhya Neelima
Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
G. Suma Latha
Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
M. Srikar
Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
B. Anuhya
Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India
V. Siva Lalitha
Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India

Abstract


The main objective of the present work was to develop controlled release matrix tablets of abacavir using different polymers namely hydroxy propyl methyl cellulose (HPMC), polyethylene oxide, pharmatose DCL 21, microcrystalline cellulose. Varying ratios of drug and polymer were selected for the study. The tablets were prepared by direct compression and wet granulation method. After evaluation of physical properties of tablet like hardness, friability, thickness, weight variation, the in vitro release study was performed by using USP type 1 dissolution apparatus in pH 6.8 phosphate buffer for 14 h. The effect of polymer concentration and polymer blend concentration were also studied. Release kinetics of abacavir matrix tablets were done by zero order, first order, higuchian square ischolar_main studies. The matrix tablets prepared with combination of HPMC K 100 M and PEO, showed slower release pattern when compared the matrix tablets prepared with HPMC K 100 M alone is clear indication of the drug release over a prolonged period. The DSC and FTIR study revealed that there was no chemical interaction between drug and excipients.

Keywords


Abacavir, HPMC, Polyox, Pharmatose, Aerosil, Controlled Release.