Preparation of Diclofenac Diethylamine Nanoemulsions by Ultrasonication-Stability and Process Parameter Evaluation Under Various Conditions

In this study, oil-in-water nanoemulsions of Diclofenac Diethylamine were produced by Ultrasonication. The influence of emulsifying conditions including emulsifier type and concentration, homogenization pressure, temperature, cycle, on time, off time and total time on the properties and stability of the nanoemulsions were investigated using a Zetasizer. The mean diameters (z-average) of the dispersed particles containing Diclofenac Diethylamine ranged from 50.57 to 154.9 nm and the polydispersity index ranged from 0.318 to 0.719 and the zeta potential ranged from19.2 to35.3. The nanoemulsions produced with Tween-80 had the smallest particle sizes and narrowest size distribution. The particle sizes decreased with increases in homogenization pressure and cycle, and also with temperature up to 40ºC. The physical stability of the nanoemulsions increased with the elevation of temperature up to 40º C, with pressure up to 200 MPa and homogenization cycle (up to three cycles).