Research Journal of Pharmaceutical Dosage Form and Technology

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Effect of Hydrotropes and Physical Properties on Solubility of Glibenclamide


Affiliations
1 Department of Pharmaceutics P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003 Andhra Pradesh, India
2 Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003, Andhra Pradesh, India
     

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The aim of present study was to increase the solubility of glibenclamide in water by hydrotropic solubilization. Sodium acetate, sodium citrate, sodium salicylate and sodium benzoate were used as the hydrotropic agents. In order to elucidate the probable mechanism of solubilization, the solution properties such as surface tension, viscosity, specific gravity were studied. Sodium salicylate was found to be the most suitable hydrotropic agent to increase the solubility of glibenclamide. The solubility of Glibenclamide by various hydrotropes was in decreasing order of Sodium acetate>sodium salicylate>sodium citrate>sodium benzoate. Initial increase in solubility of Glibenclamide was due to the weak ionic interactions between the hydrotropes and glibenclamide molecules, multifold increase in solubility at higher concentration of hydrotrope was due to molecular aggregation.

Keywords

Glibenclamide, Solubility Enhancement, Hydrotropic Agents.
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  • Effect of Hydrotropes and Physical Properties on Solubility of Glibenclamide

Abstract Views: 252  |  PDF Views: 0

Authors

P. Sabitha Reddy
Department of Pharmaceutics P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003 Andhra Pradesh, India
C. Swetha
Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003, Andhra Pradesh, India
K. Ravindra Reddy
Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003, Andhra Pradesh, India

Abstract


The aim of present study was to increase the solubility of glibenclamide in water by hydrotropic solubilization. Sodium acetate, sodium citrate, sodium salicylate and sodium benzoate were used as the hydrotropic agents. In order to elucidate the probable mechanism of solubilization, the solution properties such as surface tension, viscosity, specific gravity were studied. Sodium salicylate was found to be the most suitable hydrotropic agent to increase the solubility of glibenclamide. The solubility of Glibenclamide by various hydrotropes was in decreasing order of Sodium acetate>sodium salicylate>sodium citrate>sodium benzoate. Initial increase in solubility of Glibenclamide was due to the weak ionic interactions between the hydrotropes and glibenclamide molecules, multifold increase in solubility at higher concentration of hydrotrope was due to molecular aggregation.

Keywords


Glibenclamide, Solubility Enhancement, Hydrotropic Agents.