Design and Development of Mucoadhesive Microcapsule of Aceclofenac for Oral Controlled Release by Ionic-Gelation Technique

Microencapsulation by Ionic gelation technique is an approach to achieve controlled release of drug and mucoadhesive microcapsules were designed to improve the absorption and bioavailability of drug. Microcapsules of Aceclofenac were formulated by employing sodium alginate, two natural polymers-gum kondagogu and gum karaya. The prepared microcapsules were free flowing, discrete spherical shape was characterised by scanning electron microscopy (SEM). Microencapsulation efficiency was in the range of 60-80% and they exhibited good mucoadhesive property. Invitro dissolution data revealed that formulations exhibit the zero order kinetics and followed non-fickian diffusion transport mechanism. The GI residence time of microcapsules were studied by X-Ray photographs. In-vitro release profile of formulation (F3) was found similar to that of marketed formulation. Preclinical pharmacological activity i.e. analgesic activity was conducted. This formulation exhibited the significant analgesic activity Mucoadhesive microcapsules prepared with sodium alginate, gum karaya and gum kondagogu found to be suitable for oral controlled release.