Research Journal of Pharmaceutical Dosage Form and Technology

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Formulation and In-Vitro Evaluation of Indomethacin Microcapsules


Affiliations
1 Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh- 522101, India
2 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India
3 Deportment of Biotechnology, Achrya Nagarjuna University, Gunter, Andhra Pradesh., India
     

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The objective of this research was to formulate and evaluate the Indomethecin microcapsules for controlled drug delivery by emulsification solvent evaporation technique, employing Eutragit RL100 as coating material. Prepared microcapsules were evaluated for average particle size, Flow properties, Microencapsulation efficiency and invitro drug release studies. The drug-polymer interaction evaluated by FT-IR spectroscopy. They were found to be discrete, free flowing high percentage of drug entrapment efficiency and also retard the release for 12 hrs. The in vitro dissolution study confirmed that the formulations followed zero order kinetics and peppas release mechanism.

Keywords

Indomethacin, Eudragit RL 100,MicroCapsues,FT-IR.
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  • Formulation and In-Vitro Evaluation of Indomethacin Microcapsules

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Authors

T. V. Rao
Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh- 522101, India
S. Vidhyadhara
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India
K. R. S. Sambasivarao
Deportment of Biotechnology, Achrya Nagarjuna University, Gunter, Andhra Pradesh., India

Abstract


The objective of this research was to formulate and evaluate the Indomethecin microcapsules for controlled drug delivery by emulsification solvent evaporation technique, employing Eutragit RL100 as coating material. Prepared microcapsules were evaluated for average particle size, Flow properties, Microencapsulation efficiency and invitro drug release studies. The drug-polymer interaction evaluated by FT-IR spectroscopy. They were found to be discrete, free flowing high percentage of drug entrapment efficiency and also retard the release for 12 hrs. The in vitro dissolution study confirmed that the formulations followed zero order kinetics and peppas release mechanism.

Keywords


Indomethacin, Eudragit RL 100,MicroCapsues,FT-IR.