Development and Evaluation of Floating Matrix Tablets of Propranolol HCl

In the present investigation, an attempt was made to formulate floating matrix tablets of Propranolol HCl using tamarind gum (Tamarind Kernel Powder) with HPMC 50, HPMC K100M as release modifier. Twelve batches of floating matrix tablets of Propranolol HCl were prepared by using different drug : polymer (Propranolol HCl : HPMC 50+Tamarind gum) ratios viz. F1 (1:1), F2 (1:2), F3 (1:4), F4 (1:6), F5 (1:8), F6 (1:10) and drug : polymer (Propranolol HCl : HPMC K100M+Tamarind gum) ratios viz.F7 (1:1), F8 (1:2), F9 (1:4), F10 (1:6), F11(1:8), F12(1:10). The compressed tablets were evaluated for hardness, uniformity of weight, friability, drug content, buoyancy lag time and duration of buoyancy. All the readings are within the prescribed limits. There was no interaction between the drug, polymer and excipients it was found out by IR studies. Swelling index studies were also carried out. The in vitro release data were fitted to different order of reactions such as zero order, first order, Higuchi's reaction and Korsmeyer-Peppas reaction. It was found that, the drug release follows Korsmeyer-Peppas reaction.