Formulation and In-Vitro Evaluation of Gastroretentive Floating Microspheres of Ranitidine Hydrochloride

The present study involves preparation of floating microspheres of Ranitidine Hydrochloride with HPMC K 100, Xanthan gum and Eudragit S‐100 and in various ratios of 1: 1, 1: 2, and 1: 3. Floating microspheres were aimed to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavailability. The formulations were evaluated for FTIR, drug loading, % entrapment, particle size, SEM, buoyancy, dissolution study and the drug release kinetics. The enhanced floatability of the formulation and its retention in GIT may attribute for the increased bioavailability and decrease in frequency of administration. Comparison of three polymers revealed HPMC to be a suitable candidate for sustained release.