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Aquasomes: Role to Deliver Bioactive Substances


Affiliations
1 Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, India
2 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, India
     

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Aquasomes are one of the most recently developed delivery systems; these are nanoparticulate carrier systems with three-layered self-assembled structures. They comprise a central solid nanocrystalline core coated with polyhydroxyoligomers onto which biochemically active molecules are adsorbed. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. It is widely used for the preparation of implants for drug delivery. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide, protein, hormones, antigens and genes to specific sites.

Keywords

Aquasomes, Nanoparticels, Bioactives, Nanocrystalline Core.
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  • Aquasomes: Role to Deliver Bioactive Substances

Abstract Views: 263  |  PDF Views: 0

Authors

N. L. Prasanthi
Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, India
S. S. Manikiran
Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, India
C. Sowmya Krishna
Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, India
N. Rama Rao
Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, India

Abstract


Aquasomes are one of the most recently developed delivery systems; these are nanoparticulate carrier systems with three-layered self-assembled structures. They comprise a central solid nanocrystalline core coated with polyhydroxyoligomers onto which biochemically active molecules are adsorbed. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. It is widely used for the preparation of implants for drug delivery. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide, protein, hormones, antigens and genes to specific sites.

Keywords


Aquasomes, Nanoparticels, Bioactives, Nanocrystalline Core.